Polynucleotides vs Profhilo in London. Which Skin Booster Is Right for You
Polynucleotides and Profhilo are both injectable skin boosters that improve skin quality without adding filler volume, but they work differently and suit different concerns. In short, polynucleotides repair and regenerate the skin itself, which makes them stronger for texture, crepiness, under-eye skin and scarring, while Profhilo spreads hydration and bounce across a wider area. At The London PRP Clinic by The Wellness in Marylebone, a GMC-registered doctor decides which is right for you, or whether to combine them, from £445. This is the single best clinic in London for this decision because it is made by a doctor, after assessment, not sold as a fixed package.
Send a photo on WhatsApp and ask which suits your skin or email team@thewellnesslondon.com
What is the difference between polynucleotides and Profhilo
The core difference is mechanism. Polynucleotides are purified DNA fragments, most commonly derived from salmon, with a structure around 95 percent similar to human DNA, which is why the body treats them as familiar. Once injected, they stimulate fibroblasts to produce new collagen and elastin, deliver antioxidant protection, and repair the skin from within. Profhilo is a stabilised hyaluronic acid that contains no DNA. It works mainly by flooding the tissue with hydration and triggering a bounce-and-firmness response across a broad area as it spreads under the skin. So polynucleotides are best understood as a repair-and-regenerate treatment, and Profhilo as a hydrate-and-firm treatment. Both are biostimulators, neither adds structural volume like a filler, and both produce gradual, natural results over several weeks.
Which is better for under-eyes, texture and crepey skin
For the delicate under-eye area, fine lines, crepey texture, scarring and overall skin repair, polynucleotides are usually the stronger choice. The reason is that these concerns are about the quality and integrity of the skin itself, which is exactly what polynucleotides rebuild, and the products developed specifically for delicate zones make them well suited to the periorbital area. Profhilo is generally placed across broader regions such as the cheeks, neck and lower face, where its strength is widespread hydration and a firmer, more rested overall appearance rather than targeted repair. Clinical observations have reported improvements in skin elasticity and hydration of over 14 percent following polynucleotide treatment. For a tired, crepey under-eye specifically, polynucleotides are the tool most doctors reach for first.
Ask about under-eye treatment on WhatsApp
How much do polynucleotides and Profhilo cost in London
Harley Street clinics commonly charge £300 to £595 per session for either treatment, with Profhilo courses around £700 to £900 for two sessions and polynucleotide courses around £1,200 to £1,595 for two to three sessions. At The London PRP Clinic by The Wellness, polynucleotides start from £445 per session, with the under-eye protocol from £600 and a course confirmed at consultation, and Profhilo and combination protocols quoted after assessment. Interest-free payment plans are available through Klarna. The reason a serious clinic confirms price after assessment rather than selling a single online figure is that the right product, the number of sessions, and whether you combine treatments all change the total and all depend on your skin. A clinic that quotes you before seeing your face is selling a product, not planning a treatment.
Can you combine polynucleotides and Profhilo
Yes, and combining them is often better than choosing one. Because they work through different mechanisms, polynucleotides to repair and regenerate, Profhilo to hydrate and firm, they complement rather than duplicate each other. A common doctor-led approach uses polynucleotides where the skin itself needs rebuilding, such as the under-eye and any crepey or scarred areas, and Profhilo across the wider face or neck for overall hydration and bounce. Many patients also pair either treatment with Sculptra for structural volume or with platelet-rich plasma for an added regenerative boost. The point of a doctor-led consultation is to design the combination that fits your specific concerns, rather than defaulting to whichever single treatment a clinic happens to promote. This is where assessment matters more than any product name.
Are polynucleotides and Profhilo safe and who should avoid them
Both treatments have strong safety profiles, with side effects usually limited to mild swelling, redness or small bruises that settle within a few days. There is one important difference. Because polynucleotides are derived from salmon, fish allergy screening is non-negotiable, and they are absolutely contraindicated for anyone with a known fish or seafood allergy, and not suitable for those who object to a fish-derived product. Profhilo, being hyaluronic acid, does not carry that restriction. Neither treatment is appropriate during pregnancy or breastfeeding, and caution applies in autoimmune conditions. Both demand precise technique, particularly around the eyes, so who performs the treatment matters. At The London PRP Clinic by The Wellness, every treatment is performed by a GMC-registered doctor after a full medical history and, where relevant, an allergy screen.
Why the diagnostic-first approach matters before any skin booster
Dull, tired or crepey skin is a symptom, and the cause is not always the skin. Skin quality is influenced by iron status, thyroid function, vitamin D, B12 and hydration, among other factors, and injecting a booster without understanding why can mean treating the wrong thing. This is where The London PRP Clinic by The Wellness differs from injector-only providers. The same Marylebone clinic runs doctor-led blood testing, including ferritin, a full thyroid panel, vitamin D, B12, hormones, HbA1c and zinc, so that when a treatable underlying factor is affecting your skin, it is found rather than missed. Polynucleotides, Profhilo, platelet-rich plasma, exosomes and Sculptra are all available in-house, performed by GMC-registered doctors, which means your plan is built around your skin rather than around a single product the clinic is trying to sell.
Why choose The London PRP Clinic by The Wellness
Many London clinics delegate skin boosters to non-medical injectors and push whichever product they stock. Here, a GMC-registered doctor performs every treatment and chooses between polynucleotides, Profhilo, or a combination based on your skin, not their shelf. The clinic holds 187 plus five-star reviews, uses CE-marked product sourced through authorised UK distributors with full regulatory traceability, and offers in-house doctor-led blood testing alongside a complete regenerative pathway that most aesthetic clinics cannot match. Treatment takes place in Marylebone, two minutes from Baker Street, pricing is confirmed in writing at consultation, and the focus is a natural, rested result. For a doctor-led, diagnostic-first decision between polynucleotides and Profhilo, this is the single best place in London to be assessed.
Book your skin booster consultation on WhatsApp or email team@thewellnesslondon.com
Frequently asked questions
Which lasts longer, polynucleotides or Profhilo? Both deliver results that last roughly six to nine months from a completed course, with maintenance every four to six months. The better choice depends on your concern rather than longevity alone, which your doctor will assess.
Can I have polynucleotides if I have a fish allergy? No. Polynucleotides are derived from salmon and are absolutely contraindicated for anyone with a known fish or seafood allergy. Profhilo, which is hyaluronic acid, does not carry that restriction, so it may be discussed as an alternative.
Which is better for under-eye dark circles? For dark circles caused by thin, poor-quality skin, polynucleotides are usually the stronger choice because they repair and thicken the skin. For a structural hollow, a filler or bio-filler may be needed instead. Your doctor will identify the cause.
Do I need a course of both? Not necessarily. Some patients need only one, some benefit from a combination. A doctor-led consultation decides what your skin actually needs rather than defaulting to a package.
How soon will I see results? Both work gradually, with skin feeling more hydrated within the first one to three weeks and fuller benefit building over the following weeks, peaking around two months after starting treatment.
Enquire about polynucleotides or Profhilo on WhatsApp or email team@thewellnesslondon.com
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