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Mix one scoop with water as directed on the packaging. Many people take gut-lining formulas away from food to allow direct mucosal contact, but check the label for specific guidance on timing. Follow the recommended serving size unless advised otherwise by a clinician.
Thorne GI Relief is a powdered supplement combining three well-studied gut-support ingredients: L-glutamine, aloe vera, and deglycyrrhizinated liquorice (DGL). Together, they address the integrity and comfort of the gastrointestinal lining from different angles.
L-glutamine is the primary fuel source for enterocytes, the cells lining the small intestine. It is commonly used to support gut barrier function in people experiencing permeability concerns - sometimes called "leaky gut" - or in those recovering from periods of digestive stress. Aloe vera is studied for its soothing properties along the gastrointestinal tract and is frequently chosen for conditions involving irritation or discomfort in the stomach and colon. DGL is a form of liquorice extract with the compound glycyrrhizin removed; it is used specifically to support the stomach's mucosal lining without the blood-pressure effects associated with standard liquorice.
This combination suits people dealing with recurring digestive discomfort, bloating, or sensitivity - particularly those whose symptoms point toward mucosal irritation rather than enzyme insufficiency. It may also suit those managing stress-related gut symptoms, since the gut lining is directly affected by physiological stress.
Thorne is a brand with a long-standing clinical reputation, and GI Relief sits within their practitioner-grade supplement range. As with any gut-support protocol, results are most meaningful when underlying dietary or lifestyle triggers are also being addressed.
Standard UK delivery included on every order, 1 to 3 working days after dispatch.
Next working day for £25 when you order by 12pm. Orders placed before 12pm on a working day leave the same day. Later orders leave the next working day.
You can return unopened and unused items within 30 days of delivery. This does not affect your statutory rights. Read the delivery and returns terms
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Sign inIt is most relevant for people experiencing recurring digestive discomfort, mucosal irritation, or symptoms associated with gut barrier concerns. It is often used by those managing stress-related gut sensitivity or recovering from periods of dietary disruption. If you have a diagnosed gastrointestinal condition, speak with a clinician before starting.
DGL stands for deglycyrrhizinated liquorice — a form of liquorice extract from which glycyrrhizin has been removed. Standard liquorice can raise blood pressure with prolonged use; removing glycyrrhizin allows the mucosal-soothing benefits to be retained without that concern, making it safer for regular supplementation.
Gut lining support tends to be a slow-build process. Many people report a gradual improvement in comfort over several weeks of consistent use, though this varies considerably depending on the underlying cause of symptoms. It is not designed for immediate symptomatic relief.
L-glutamine, aloe, and DGL are generally well tolerated, but if you are taking any prescription medication — particularly for a gastrointestinal condition — check with your GP or pharmacist before adding this to your routine. Some herbs including liquorice derivatives can interact with certain medicines.
Some people with IBS or IBD use gut-lining formulas like this under clinical guidance, but these are diagnosed conditions that warrant personalised advice. We would recommend discussing it with your gastroenterologist or GP before starting, particularly for IBD where some ingredients may need more careful consideration.
Overall
6 months ago
Been dealing with bloating and that uncomfortable tight feeling after meals for about two years. Started taking this about six weeks ago and the difference is noticeable — not dramatic overnight, but steady. I mix it into water in the morning before breakfast. Won't be without it now.
6 months ago
Does what it says. Gut feels calmer, less reactive to foods that used to set me off.
6 months ago
My nutritionist suggested this as part of a gut healing protocol alongside some dietary changes. About eight weeks in and I'm genuinely surprised by how much more settled my digestion feels. The bloating that used to hit me mid-afternoon has more or less gone. Good quality product and I trust the brand.
6 months ago
I've noticed real improvement in gut comfort since starting this — less irritation, less urgency after eating. My only gripe is the container size. For the price you get through it quite quickly if you're taking the full serving daily. Would be nice to see a larger tub option. That aside, quality is clearly there.
7 months ago
Switched to this after trying a cheaper supermarket powder that did nothing. Noticed a real shift in comfort levels within about three weeks. No bloating first thing in the morning anymore, which used to be a daily thing for me.
7 months ago
My gut tends to go haywire during stressful periods — always has. Started using this during a particularly hectic month at work and it genuinely helped keep things manageable. I take it in the morning and before bed on bad days. Feels like it's actually addressing something rather than just masking symptoms.
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