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A synergistic four-botanical formula combining berberine, milk thistle, burdock root, and chicory root to support bile production, enhance liver detoxification pathways, and protect hepatocytes - the practitioner-grade liver support that addresses the organ processing everything you eat, drink, breathe, and absorb. Your liver performs over 500 functions. It filters every millilitre of blood returning from your digestive tract before it reaches the rest of your body.
It metabolises alcohol, medications, hormones, and environmental chemicals. It produces bile for fat digestion and fat-soluble vitamin absorption. It stores glycogen for energy regulation, synthesises proteins for blood clotting, and processes the ammonia produced by protein metabolism into urea for safe excretion.
No other organ in your body handles this breadth of biochemical responsibility, and no other organ operates under this level of continuous demand. You do not feel your liver working, which is precisely why you do not notice when it is struggling - until fatigue deepens, digestion deteriorates, skin dulls, hormonal balance shifts, and the vague sense that something is off becomes a permanent background hum.
Modern life places unprecedented demands on liver function. Alcohol, processed food, refined sugar, pharmaceutical medications, environmental pollutants, pesticide residues, heavy metals, synthetic hormones, and the metabolic byproducts of chronic stress all funnel through the same hepatic detoxification pathways. Phase I enzymes (primarily cytochrome P450) activate toxins for processing. Phase II enzymes conjugate them for safe excretion. Bile carries the processed waste into the intestines for elimination.
When any stage is overwhelmed - when the volume of incoming substances exceeds the liver's processing capacity - intermediary metabolites accumulate, bile flow stagnates, and the organ that is supposed to protect you from toxicity becomes a bottleneck that perpetuates it. Most people never consider liver support because they associate liver problems with disease. But the gap between optimal liver function and liver disease is wide, and most of the population sits somewhere in that gap, running a detoxification system at reduced capacity without ever crossing a clinical threshold.
Thorne Liver Cleanse addresses this with four botanicals that target complementary aspects of liver function. Berberine HCl (125 mg, from Berberis aristata) stimulates bile production and flow, supports phase I and phase II detoxification enzyme activity, and provides antimicrobial action in the gut that reduces the endotoxin load reaching the liver via the portal vein. Milk Thistle extract (125 mg, standardised to 65% silymarin) is the most extensively researched hepatoprotective botanical in existence - silymarin stabilises liver cell membranes, promotes hepatocyte regeneration, and acts as a potent antioxidant that neutralises free radicals generated during detoxification. Burdock root extract (100 mg) is a traditional cleansing botanical that supports the elimination of metabolic waste products through both hepatic and renal pathways, while providing prebiotic inulin that feeds beneficial gut bacteria. Chicory root extract (100 mg) is a cholagogue - it stimulates the production and release of bile, enhancing the liver's ability to excrete the toxins it has processed and preventing biliary stagnation. Together, these four botanicals create a complete support system: bile production is stimulated, detoxification pathways are enhanced, liver cells are protected, and waste elimination is promoted.
Thorne is NSF Certified for Sport, third-party tested through four rounds of quality verification, and trusted by over 47,000 healthcare practitioners worldwide. Vegetarian capsule. No gluten, dairy, soy, artificial colours, or preservatives. 60 capsules per bottle.
Standard UK delivery included on every order, 1 to 3 working days after dispatch.
Next working day for £25 when you order by 12pm. Orders placed before 12pm on a working day leave the same day. Later orders leave the next working day.
You can return unopened and unused items within 30 days of delivery. This does not affect your statutory rights. Read the delivery and returns terms
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Your first order creates it. Add your blood results or a wearable, and a doctor can recommend what suits you.
Sign inIt is most relevant for people who have identified elevated liver enzymes or reduced glutathione capacity via blood testing, those on long-term medications that are metabolised hepatically, or individuals managing metabolic conditions such as non-alcoholic fatty liver disease. It is not a substitute for medical assessment.
NAC and alpha lipoic acid can interact with certain chemotherapy agents, and milk thistle may affect how the liver metabolises some medications by influencing cytochrome P450 enzymes. Speak to your GP or prescribing clinician before adding this if you are on any regular medication.
Liver support supplements are not typically felt acutely. Any meaningful change is more likely to be reflected in blood markers over weeks to months. We would suggest retesting liver enzymes or relevant biomarkers after 8–12 weeks of consistent use.
There is insufficient safety data to recommend NAC or high-dose alpha lipoic acid during pregnancy or breastfeeding. Consult your doctor before use.
No. This supplement may support the liver's natural processes, but it does not increase the liver's capacity to handle excess alcohol or offset medication toxicity. It is not a licence to increase intake of either.
Overall
6 months ago
My GP flagged slightly elevated liver enzymes at my annual check-up and suggested I look into some support while we monitored. A friend who's a nutritionist pointed me toward this. Retested after about 8 weeks and my numbers had come down to within normal range. Can't say it's solely down to this — I also cut back on alcohol — but I'm keeping it in the rotation.
6 months ago
Take this alongside my omega-3s and magnesium before bed. Been on it about three months now. Hard to point to one dramatic change but I feel less sluggish in the mornings and my digestion feels smoother. Sensible formulation — nothing gimmicky in the ingredients list.
6 months ago
Recommended by my integrative GP after some bloodwork. Happy with the quality, capsules are easy to swallow. Will re-order.
6 months ago
The formula itself seems solid — I've been taking it for six weeks and feel like my digestion and energy have evened out a bit. My only gripe is the capsule size. They're noticeably bigger than most supplements I take and I do have to wash them down with a decent amount of water. Not a dealbreaker but worth knowing.
7 months ago
Bought after reading about milk thistle and NAC for liver support. The fact that this combines both plus alpha lipoic acid made it a no-brainer vs buying three separate things. Straightforward, no fuss. Would buy again.
7 months ago
I'd been taking a cheaper milk thistle on its own for ages. Swapped to this and the combined formula feels much more comprehensive. Noticed I'm less puffy after weekends. Staying on this.
Biomarker check, £350MaryleboneSee your vitamin D, iron and B12.At our clinic in Marylebone, London, doctors also offer private blood tests and private GP appointments.
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