Longevity Box Apigenin

Name: Longevity Box Apigenin
Brand: Longevity Box
SKU: product-0358
Price: 20.00 GBP
Availability: InStock
Rating: 4.8 (8 reviews)

£20.00

Apigenin is a naturally occurring flavonoid found in chamomile, parsley, and celery.

May support NAD+ levels by inhibiting CD38 activity
Studied for anti-inflammatory effects via flavonoid pathways
May promote calmness and improve sleep quality
Complements NMN or NR in longevity-focused supplement stacks
Single-ingredient formula suited to precise, stackable protocols

4.8 (8 reflections)

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Longevity BoxLongevity Box Apigenin

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about this product.

Apigenin is a naturally occurring flavonoid found in chamomile, parsley, and celery. This supplement delivers it in a concentrated daily capsule format. In research settings, apigenin is studied primarily for its role in NAD+ metabolism — it inhibits CD38, an enzyme that consumes NAD+ as we age, which has made it a focus of longevity-oriented nutrition protocols. Declining NAD+ levels are associated with reduced cellular energy production, impaired DNA repair, and accelerated biological ageing. By supporting NAD+ availability, apigenin may complement other longevity-focused supplements such as NMN or NR.

Beyond its role in cellular metabolism, apigenin is also studied for its interaction with GABA receptors, which may help support a calmer mental state and contribute to sleep quality. It has demonstrated anti-inflammatory properties in laboratory and animal studies, though large-scale human trials remain limited.

This supplement suits those already engaging seriously with longevity nutrition — particularly people taking NAD+ precursors who want to address the CD38 drain side of the equation. It also appeals to individuals looking for a botanically derived sleep-support option. The formulation is straightforward: a single active ingredient at a defined dose, with no unnecessary additions. That simplicity makes it easy to stack without concern about overlapping ingredients.

frequently asked.

How does apigenin relate to NAD+ supplements like NMN or NR?

NMN and NR are precursors that help the body produce more NAD+. CD38, an enzyme that increases with age, rapidly consumes NAD+ and can undermine that effort. Apigenin is studied for its ability to inhibit CD38, so the two approaches may work in a complementary way — though speak to a clinician before combining multiple longevity supplements.

Can I take this if I am on medication?

Apigenin is a flavonoid compound and may interact with certain medications, particularly those metabolised by the CYP450 liver enzyme pathway. If you are on any prescribed medicines, check with your GP or pharmacist before starting.

Will this help me sleep?

Apigenin is studied for its mild interaction with GABA-A receptors, which may support a calmer mental state and contribute to sleep onset. It is not a sedative, but some people find taking it in the evening fits well with their wind-down routine.

How long before I might notice a difference?

For sleep-related effects, some users notice a difference within the first week or two. Effects related to NAD+ metabolism and cellular longevity are longer-term and unlikely to be subjectively felt — they are better assessed through periodic blood biomarker testing.

Is this suitable for vegetarians or vegans?

The packaging will confirm the capsule shell material and any excipients. Check the label directly, as we cannot confirm this from the product listing alone.

Customer reflections

Overall sentiment

4.88 reflections

1 – 6 of 8 reflections

QQVerified Buyer

The first adrenal support that made a quick difference.

4 days ago

Gentle on a sensitive stomach, and I feel like myself again. I had tried two other glandulars before this and neither sat right.

MRVerified Buyer

Steadier mornings within a fortnight.

1 week ago

I was sceptical about glandulars, but my mid-afternoon crash has genuinely eased. One capsule with breakfast and I forget about it.

ALVerified Buyer

Subtle, but real.

2 weeks ago

Not a stimulant, which is exactly what I wanted. It took about ten days, then I realised I wasn’t dreading the afternoon any more.

SKVerified Buyer

My clinician recommended it.

3 weeks ago

Bought after a blood panel flagged a flat cortisol curve. Easy to take, no jitters, and the sourcing is refreshingly transparent.

TPVerified Buyer

Recovery feels faster.

1 month ago

Training hard through a stressful stretch and this has helped me bounce back between sessions. Already on my second bottle.

DVVerified Buyer

Does what it says.

1 month ago

No frills, one ingredient, a sensible dose. I appreciate that it is designed to be used for a season rather than forever.

Longevity Box Apigenin

about this product.

how to take it

frequently asked.

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Customer reflections