Free standard delivery Longevity Box Longevity Box Apigenin

Longevity Box Apigenin

Name: Longevity Box Apigenin
Brand: Longevity Box
SKU: product-0358
Price: 20.00 GBP
Availability: InStock
Rating: 4.8 (8 reviews)

£20.00

Apigenin is a naturally occurring flavonoid found in chamomile, parsley, and celery.

May support NAD+ levels by inhibiting CD38 activity
Studied for anti-inflammatory effects via flavonoid pathways
May promote calmness and improve sleep quality
Complements NMN or NR in longevity-focused supplement stacks
Single-ingredient formula suited to precise, stackable protocols

4.8 (8 reflections)

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About This Product.

Apigenin is a naturally occurring flavonoid found in chamomile, parsley, and celery. This supplement delivers it in a concentrated daily capsule format. In research settings, apigenin is studied primarily for its role in NAD+ metabolism — it inhibits CD38, an enzyme that consumes NAD+ as we age, which has made it a focus of longevity-oriented nutrition protocols. Declining NAD+ levels are associated with reduced cellular energy production, impaired DNA repair, and accelerated biological ageing. By supporting NAD+ availability, apigenin may complement other longevity-focused supplements such as NMN or NR.

Beyond its role in cellular metabolism, apigenin is also studied for its interaction with GABA receptors, which may help support a calmer mental state and contribute to sleep quality. It has demonstrated anti-inflammatory properties in laboratory and animal studies, though large-scale human trials remain limited.

This supplement suits those already engaging seriously with longevity nutrition — particularly people taking NAD+ precursors who want to address the CD38 drain side of the equation. It also appeals to individuals looking for a botanically derived sleep-support option. The formulation is straightforward: a single active ingredient at a defined dose, with no unnecessary additions. That simplicity makes it easy to stack without concern about overlapping ingredients.

Frequently Asked.

How does apigenin relate to NAD+ supplements like NMN or NR?

NMN and NR are precursors that help the body produce more NAD+. CD38, an enzyme that increases with age, rapidly consumes NAD+ and can undermine that effort. Apigenin is studied for its ability to inhibit CD38, so the two approaches may work in a complementary way — though speak to a clinician before combining multiple longevity supplements.

Can I take this if I am on medication?

Apigenin is a flavonoid compound and may interact with certain medications, particularly those metabolised by the CYP450 liver enzyme pathway. If you are on any prescribed medicines, check with your GP or pharmacist before starting.

Will this help me sleep?

Apigenin is studied for its mild interaction with GABA-A receptors, which may support a calmer mental state and contribute to sleep onset. It is not a sedative, but some people find taking it in the evening fits well with their wind-down routine.

How long before I might notice a difference?

For sleep-related effects, some users notice a difference within the first week or two. Effects related to NAD+ metabolism and cellular longevity are longer-term and unlikely to be subjectively felt — they are better assessed through periodic blood biomarker testing.

Is this suitable for vegetarians or vegans?

The packaging will confirm the capsule shell material and any excipients. Check the label directly, as we cannot confirm this from the product listing alone.

Customer Reflections

Overall Sentiment

4.88 reflections

1 – 6 of 8 reflections

Solid addition to my NMN stack

5 months ago

Been taking NMN for about eight months and added this a couple of months back after reading about the CD38 side of things. Hard to isolate exactly what's doing what, but sleep feels noticeably more settled and I wake up less groggy. Clean formula, nothing unnecessary in it. Will keep reordering.

Better sleep, didn't expect that

6 months ago

Bought this primarily for the NAD+ angle but honestly the sleep improvement was the first thing I clocked. Falling asleep faster, staying asleep. A few weeks in and I'm impressed enough to have already ordered a second bottle. Good price for what it is too.

Good product, capsules are a bit large

6 months ago

Does what I'd hope — stacking it with NR and it seems to be a sensible pairing. My only gripe is the capsule size, they're on the bigger end and I do occasionally struggle to swallow them with my morning stack. Not a dealbreaker but worth noting if you're sensitive to that sort of thing. Would still recommend.

7 months ago

Switched over from a combined supplement that had apigenin as one of several ingredients. Prefer having it standalone — easier to adjust what I'm doing. Noticed a calmer evenings generally, which I wasn't expecting but definitely appreciate.

Simple, clean, effective

8 months ago

Love a single-ingredient supplement. No guessing what's doing what. I take this with my NMN in the morning and have done for about three months now. Slightly better focus in the afternoons — could be placebo, could be real. Either way I'm not stopping. Good value at this price point.

Good, but the pot only lasts 30 days

9 months ago

Really happy with the product itself — I take it in the evening and it does seem to take the edge off before bed. My gripe is purely the container size; 30 capsules goes quickly and I'd much rather a 60 or 90 day supply to reduce how often I'm reordering. The quality is there though, and the price per capsule is fair enough.

Longevity Box Apigenin

About This Product.

How to Take It

Frequently Asked.

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