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Thorne has earned its place in our dispensary because it applies manufacturing discipline that most supplement brands do not match. NiaCel 400 specifically uses a well-characterised form of nicotinamide riboside at a research-consistent dose. We recommend it for patients where NAD+ biology is a genuine clinical focus — not as a general tonic, but as a targeted intervention with a credible mechanism behind it.
About this product
NiaCel 400
Thorne NiaCel 400 is a nicotinamide riboside supplement, delivering 400 mg of this NAD+ precursor per serving. Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into nicotinamide adenine dinucleotide (NAD+), a coenzyme central to cellular energy metabolism and DNA repair. NAD+ levels decline with age, and this decline is associated with reduced mitochondrial function and slower cellular recovery. NR is studied as one of the more bioavailable routes to raising NAD+ compared to standard niacin.
This supplement suits people who are actively monitoring their metabolic health, those in demanding physical training, or anyone whose blood work or clinical assessment has flagged concerns around energy metabolism and cellular ageing. It fits naturally into a morning routine alongside other foundational nutrition support.
Thorne is a brand with a long-standing reputation for rigorous quality standards in supplement manufacturing. NiaCel 400 uses a well-characterised form of nicotinamide riboside at a dose consistent with the amounts used in human research. For those working with a clinician to address age-related metabolic decline or optimising cellular resilience, this is a considered, evidence-informed choice rather than a speculative one.
What it does
Benefits
- 01
Raises NAD+ levels to support cellular energy metabolism
- 02
May support mitochondrial function in ageing adults
- 03
Studied form of vitamin B3 with good bioavailability
- 04
Relevant for those managing age-related metabolic decline
- 05
Suits high-output athletes monitoring cellular recovery
Get the most from it
How to use
Take 1 capsule twice daily, or as directed by your healthcare practitioner. NR is generally well tolerated with or without food. Many people take it in the morning to align with daytime energy metabolism.
What's inside
Ingredients
View full ingredient list
Nicotinamide Riboside 400mg
Common questions
Frequently asked
What is nicotinamide riboside and how does it differ from regular niacin?
Nicotinamide riboside is a form of vitamin B3 that converts to NAD+ via a distinct metabolic pathway. Unlike standard niacin, it does not typically cause the skin flushing that many people find uncomfortable, making it easier to take consistently.
How long before I notice a difference?
Human studies on NR generally run over several weeks before measuring outcomes. Most people would not expect to notice a pronounced subjective effect quickly — NAD+ support works at a cellular level rather than producing an immediate sensation. Allow at least four to eight weeks before assessing impact.
Who should avoid this supplement?
People who are pregnant, breastfeeding, or taking medications that affect NAD+ metabolism or liver function should consult a clinician before starting. As with any B3-related compound, those with liver conditions warrant medical supervision.
Can I take NiaCel 400 alongside other supplements or medications?
NR is generally considered low-risk alongside standard supplements, but if you are taking chemotherapy agents, resveratrol at high doses, or medications processed by the liver, speak to your doctor first. Check the packaging and consult your prescriber if in doubt.
Does this need to be refrigerated?
Check the packaging for storage instructions specific to this product. As a general principle, NAD+ precursors are best stored away from heat, moisture, and direct light to preserve stability.
Doctor-guided care
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