Over 25 essential nutrients in a single daily tablet — featuring bioavailable forms most multivitamins skip, including 5-MTHF folate, methylcobalamin B12, L-OptiZinc, all four forms of vitamin E, and three forms of selenium — from the brand that has spent 40+ years advancing nutritional science.
Most people take a multivitamin and assume the job is done. The reality is that the majority of high-street multivitamins use the cheapest, least absorbable forms of every nutrient — folic acid instead of methylfolate, cyanocobalamin instead of methylcobalamin, zinc oxide instead of chelated zinc, dl-alpha tocopherol instead of the full vitamin E spectrum. These synthetic or poorly bioavailable forms look adequate on the label but deliver a fraction of their stated value to your cells. You swallow a tablet every morning, trust that it is working, and your body excretes most of what it cannot absorb. The multivitamin market is built on the assumption that consumers will never check the forms on the back of the bottle — and for decades, that assumption has held.
The consequences of cheap formulation are not dramatic enough to notice on any single day, but they compound over years. Suboptimal B vitamin intake contributes to fatigue, poor methylation, and elevated homocysteine. Insufficient zinc in a poorly absorbed form leaves immune function, skin integrity, and hormonal balance unsupported. A single form of vitamin E misses the gamma, delta, and beta tocopherols that provide the majority of vitamin E's antioxidant and anti-inflammatory activity. Folic acid — the synthetic form — requires enzymatic conversion that approximately 40% of the population performs inefficiently due to MTHFR gene variants, meaning nearly half of all multivitamin users may be getting negligible folate benefit from their daily tablet. You pay for 25 nutrients. Your body receives a fraction.
Life Extension One-Per-Day was formulated to eliminate this gap. Every nutrient form was selected for bioavailability and clinical relevance. 5-MTHF (5-methyltetrahydrofolate calcium salt) is the biologically active form of folate — no conversion required, effective regardless of MTHFR status. Methylcobalamin is the active, coenzyme form of B12 that your nervous system uses directly. L-OptiZinc (zinc mono-L-methionine sulphate) is a patented chelated zinc with superior absorption and retention compared to standard zinc oxide or gluconate. All four forms of vitamin E — alpha, beta, gamma, and delta tocopherols — provide the full spectrum of antioxidant protection rather than the isolated alpha-tocopherol that most multivitamins rely on.
Three forms of selenium — sodium selenite, SelenoExcell high-selenium yeast, and Se-methyl L-selenocysteine — provide broad-spectrum selenium activity across multiple metabolic pathways. Vitamin D3 at 2000 IU supports immune function, bone health, and mood. Alpha-lipoic acid, lycopene, quercetin, and marigold extract round out the formula with targeted antioxidant and phytonutrient support.
Life Extension has been at the forefront of preventative nutritional science for over 40 years, backed by a team of physicians, researchers, and nutritional scientists. Over 400 products across 40+ health categories. Soy-free, gluten-free, non-GMO. 60 tablets per bottle — a two-month supply at one tablet daily.
- 5-MTHF folate — biologically active, effective regardless of MTHFR gene status
- Methylcobalamin B12 — the coenzyme form your nervous system uses directly
- L-OptiZinc — patented chelated zinc with superior absorption and retention
- All four vitamin E tocopherols — alpha, beta, gamma, and delta for full-spectrum protection
- Three selenium forms — broad-spectrum coverage across multiple metabolic pathways
- Vitamin D3 2000 IU for immune, bone, and mood support
- Alpha-lipoic acid, lycopene, quercetin, and marigold extract for targeted antioxidant defence
B vitamins and magnesium contribute to the reduction of tiredness and fatigue
Vitamin C, zinc, and selenium contribute to normal immune system function
One tablet daily — 60 tablets, two-month supply
Soy-free, gluten-free, non-GMO — 40+ years of nutritional science
People who read the back of the bottle before they buy understand that a multivitamin is only as effective as the forms it uses. Choosing bioavailable, clinically selected nutrient forms reflects a refusal to pay for a label while your body receives a fraction.
You gain methylation support, which removes the bottleneck created by synthetic folic acid in MTHFR variant carriers and enables efficient folate metabolism through the biologically active 5-MTHF form
You gain full-spectrum antioxidant protection, which removes the incomplete coverage of single-form vitamin E and isolated selenium and enables broad defence across four tocopherols and three selenium compounds
You gain immune foundation, which removes the gaps left by poorly absorbed zinc, vitamin C, and selenium forms and enables consistent daily support through patented L-OptiZinc, ascorbate-complex vitamin C, and triple-source selenium
You gain energy and fatigue reduction, which removes the dragging tiredness associated with suboptimal B vitamin and magnesium intake and enables sustained energy production through bioavailable cofactors your metabolism depends on
You gain bone and mood support, which removes the deficiency risk created by inadequate vitamin D3 and magnesium and enables maintained skeletal density and emotional equilibrium — particularly through darker months
