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Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes.
£55
Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes.
Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes.
Take 1 capsule one to three times daily, as directed on the packaging. Taking capsules with a meal is generally advisable for phospholipid supplements. Adjust the number of capsules to your specific use case - lower end for general maintenance, higher end during periods of elevated stress or training load.
Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes. It plays a role in maintaining membrane fluidity and supporting the signalling pathways involved in cognition, memory, and the body's cortisol response to stress.
Phosphatidylserine is one of the more studied nootropic-adjacent nutrients. The research base centres on age-related cognitive decline, working memory, and attentional performance - making it most relevant for adults noticing early memory lapses, those in cognitively demanding roles, or people managing high chronic stress loads where cortisol dysregulation is a concern. It is also used by athletes interested in blunting the cortisol spike following intense training.
It fits naturally into a morning or pre-training routine, taken alongside a meal. Because it supports membrane integrity broadly, some users combine it with omega-3 fatty acids, though that is a general category observation rather than a specific formulation claim.
Thorne is a brand our clinicians return to consistently. Their manufacturing standards are well-regarded within the practitioner community, and they tend to use clean, well-characterised ingredient forms. Phosphatidylserine at 100 mg per capsule allows flexible dosing across different use cases, from a single daily capsule for general brain health maintenance to higher intakes during periods of elevated cognitive or physical demand.
Standard UK delivery included on every order, 1 to 3 working days after dispatch.
Next working day for £25 when you order by 12pm. Orders placed before 12pm on a working day leave the same day. Later orders leave the next working day.
You can return unopened and unused items within 30 days of delivery. This does not affect your statutory rights. Read the delivery and returns terms
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Sign inAdults experiencing age-related memory changes, those in high-stress or cognitively demanding roles, and athletes looking to support recovery by moderating post-exercise cortisol are the most studied groups. It is not a general-population supplement — it suits a specific need.
Cognitive and stress-related benefits from phosphatidylserine tend to be gradual. Most research protocols run over several weeks to months, so a short trial of a few days is unlikely to be informative. Consistent daily use over at least four to six weeks is a more realistic assessment window.
Phosphatidylserine is generally well tolerated, but if you are taking anticoagulants or anticholinergic medications, speak to your GP or clinician before starting. As with any supplement, disclose it to your prescribing doctor as part of your full picture.
Taking it with food is preferable. Phospholipids are fat-soluble compounds and are generally better absorbed alongside a meal containing some dietary fat.
The 100 mg capsule format mirrors the lower end of doses used in cognitive research, while the one-to-three capsules daily range allows you to match intake to your goals. Check the label and, if in doubt, start at the lower end and discuss adjustments with a clinician.
Overall
6 months ago
Been taking two capsules in the morning for about six weeks now. My job involves a lot of back-to-back meetings and detailed analysis, and I genuinely feel sharper through the afternoon than I used to. Hard to say how much is this versus better sleep, but I've kept everything else constant. Will carry on.
6 months ago
I take this alongside omega-3 and a B-complex. Started it about two months ago after reading up on cortisol and stress. I work in finance, so the mental load is relentless. Hard to isolate any single supplement but I've felt calmer after training sessions and my brain fog in the mornings has mostly gone.
6 months ago
Straightforward supplement, clean ingredients, no fillers I need to worry about. That matters to me.
6 months ago
The quality is clearly there and I've noticed I'm a bit more on the ball after a few weeks. My only gripe is the value — £52.99 for the bottle feels steep when you're taking two a day, which means you're through it in three weeks. Would love a larger format option.
7 months ago
I'm a competitive cyclist and started using this before a big training block. I take it straight after my long rides. Can't measure cortisol obviously, but I feel less mentally wrecked in the evenings than I used to. Sleep has been better too, though that could be a few things.
7 months ago
Recommended by a friend who swears by it for memory. I've been on it five weeks and I do feel more present. Nothing dramatic, just less of that word-on-the-tip-of-your-tongue frustration.
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