Phosphatidylserine

Name: Phosphatidylserine
Brand: Thorne
SKU: product-0518
Price: 55.00 GBP
Availability: InStock
Rating: 4.8 (25 reviews)

£55.00

Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes.

Supports memory and cognitive function in adults
May help moderate cortisol response to physical stress
Maintains neuronal cell membrane integrity
Suited to high-stress or cognitively demanding lifestyles
Flexible dosing for maintenance or intensive use

4.8 (25 reflections)

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About This Product.

Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes. It plays a role in maintaining membrane fluidity and supporting the signalling pathways involved in cognition, memory, and the body's cortisol response to stress.

Phosphatidylserine is one of the more studied nootropic-adjacent nutrients. The research base centres on age-related cognitive decline, working memory, and attentional performance — making it most relevant for adults noticing early memory lapses, those in cognitively demanding roles, or people managing high chronic stress loads where cortisol dysregulation is a concern. It is also used by athletes interested in blunting the cortisol spike following intense training.

It fits naturally into a morning or pre-training routine, taken alongside a meal. Because it supports membrane integrity broadly, some users combine it with omega-3 fatty acids, though that is a general category observation rather than a specific formulation claim.

Thorne is a brand our clinicians return to consistently. Their manufacturing standards are well-regarded within the practitioner community, and they tend to use clean, well-characterised ingredient forms. Phosphatidylserine at 100 mg per capsule allows flexible dosing across different use cases, from a single daily capsule for general brain health maintenance to higher intakes during periods of elevated cognitive or physical demand.

How to Take It

Take 1 capsule one to three times daily, as directed on the packaging. Taking capsules with a meal is generally advisable for phospholipid supplements. Adjust the number of capsules to your specific use case — lower end for general maintenance, higher end during periods of elevated stress or training load.

Frequently Asked.

Who is most likely to benefit from phosphatidylserine?

Adults experiencing age-related memory changes, those in high-stress or cognitively demanding roles, and athletes looking to support recovery by moderating post-exercise cortisol are the most studied groups. It is not a general-population supplement — it suits a specific need.

How long before I notice a difference?

Cognitive and stress-related benefits from phosphatidylserine tend to be gradual. Most research protocols run over several weeks to months, so a short trial of a few days is unlikely to be informative. Consistent daily use over at least four to six weeks is a more realistic assessment window.

Is it safe to take alongside other supplements or medications?

Phosphatidylserine is generally well tolerated, but if you are taking anticoagulants or anticholinergic medications, speak to your GP or clinician before starting. As with any supplement, disclose it to your prescribing doctor as part of your full picture.

Can I take it on an empty stomach?

Taking it with food is preferable. Phospholipids are fat-soluble compounds and are generally better absorbed alongside a meal containing some dietary fat.

How does the 100 mg per capsule dosing work in practice?

The 100 mg capsule format mirrors the lower end of doses used in cognitive research, while the one-to-three capsules daily range allows you to match intake to your goals. Check the label and, if in doubt, start at the lower end and discuss adjustments with a clinician.

Customer Reflections

Overall Sentiment

4.825 reflections

1 – 6 of 25 reflections

Noticeable difference in focus

4 months ago

Been taking two capsules in the morning for about six weeks now. My job involves a lot of back-to-back meetings and detailed analysis, and I genuinely feel sharper through the afternoon than I used to. Hard to say how much is this versus better sleep, but I've kept everything else constant. Will carry on.

Solid addition to my morning stack

4 months ago

I take this alongside omega-3 and a B-complex. Started it about two months ago after reading up on cortisol and stress. I work in finance, so the mental load is relentless. Hard to isolate any single supplement but I've felt calmer after training sessions and my brain fog in the mornings has mostly gone.

Does exactly what it promises

5 months ago

Straightforward supplement, clean ingredients, no fillers I need to worry about. That matters to me.

Good product, pricey for the capsule count

5 months ago

The quality is clearly there and I've noticed I'm a bit more on the ball after a few weeks. My only gripe is the value — £52.99 for the bottle feels steep when you're taking two a day, which means you're through it in three weeks. Would love a larger format option.

Great for post-training recovery focus

5 months ago

I'm a competitive cyclist and started using this before a big training block. I take it straight after my long rides. Can't measure cortisol obviously, but I feel less mentally wrecked in the evenings than I used to. Sleep has been better too, though that could be a few things.

5 months ago

Recommended by a friend who swears by it for memory. I've been on it five weeks and I do feel more present. Nothing dramatic, just less of that word-on-the-tip-of-your-tongue frustration.

Phosphatidylserine

About This Product.

How to Take It

Frequently Asked.

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