
Vitamin D3 + K2 liquid drops
Vitamin D3 + K2 Liquid Drops deliver two fat-soluble nutrients that are commonly considered together: D3 as cholecalciferol — the form most readily converted a…

£95.00
Tru Niagen PRO 1000mg is a high-dose nicotinamide riboside (NR) supplement from ChromaDex, the company that pioneered and holds the foundational patents on NR as a consumer ingredient.
Secure checkoutFree standard delivery on all orders30-day returns
ChromadexTru Niagen PRO 1000mg
Vitamin D3 + K2 Liquid Drops deliver two fat-soluble nutrients that are commonly considered together: D3 as cholecalciferol — the form most readily converted a…

60 billion AFU of Akkermansia muciniphila plus 64 billion CFU of Lactobacillus acidophilus, 700 mg berberine, 200 mg inulin, 2.4 mg astaxanthin, and chromium i…
Interested in more
personalised recommendations?
Set up your
Profile to connect your wearables, biomarkers and test results. Create a bespoke plan based on your unique biology. Expert-led, evidence-based.
Tru Niagen PRO 1000mg is a high-dose nicotinamide riboside (NR) supplement from ChromaDex, the company that pioneered and holds the foundational patents on NR as a consumer ingredient. Nicotinamide riboside is a form of vitamin B3 that serves as a direct precursor to NAD+, a coenzyme central to cellular energy metabolism, DNA repair, and mitochondrial function. NAD+ levels decline measurably with age, and NR is one of the more studied oral strategies for raising them.
This formulation is suited to those who have made an informed decision to support NAD+ levels at a meaningful dose — whether for general longevity interest, during periods of physiological stress, or alongside medical guidance for conditions where mitochondrial support is relevant. At this dose, it sits at the higher end of the NR range available without prescription.
ChromaDex supplies NR as NIAGEN to many other supplement brands, so sourcing it direct from ChromaDex means you are working with the originator of the ingredient. The science around NR continues to mature; human trials have consistently shown that oral NR raises whole-blood NAD+ levels, though the downstream health implications of this are still being studied. This is a supplement to sit alongside a sensible diet and lifestyle, not a replacement for understanding your baseline through blood testing.
Nicotinamide Riboside 1000mg

Take 2 capsules daily, as directed on the packaging. Many users take NR in the morning with or without food, as it does not typically require food for absorption. Consistency over weeks is more relevant than timing.
Nicotinamide riboside (NR), niacin, and NMN are all NAD+ precursors but follow different biochemical pathways to get there. NR is generally better tolerated than niacin (which can cause flushing) and has a more established human trial record than NMN at this stage. They are not interchangeable, though they share the same end goal of raising NAD+.
Human studies have shown measurable increases in blood NAD+ levels within two to four weeks of consistent NR supplementation. Subjective changes — if any — tend to be subtle; this is not a supplement with an immediate, noticeable effect for most people. Think of it as a long-term investment rather than a short-term fix.
NR is generally considered well-tolerated, but if you are taking medications — particularly those affecting DNA repair pathways or cancer treatments — speak to your doctor before adding a high-dose NAD+ precursor. As with any supplement at this dose, a clinical conversation is worthwhile if you have an underlying condition.
Pregnant or breastfeeding individuals should avoid NR supplements unless advised otherwise by a clinician, as safety data in these groups is limited. Those with a history of certain cancers should consult their oncologist, given that NAD+ plays a role in cell proliferation pathways.
ChromaDex manufactures NIAGEN, the NR ingredient that many competing brands actually buy from them and repackage. Purchasing Tru Niagen PRO means you are buying directly from the source. The price also reflects the higher dose format — check the per-milligram cost against alternatives before assuming it is less competitive.
We offer physician-led talks and events to help you learn more about how to deal with stress through movement, mindfulness, and refocusing.
Learn about our next event
Overall Sentiment
5 months ago
Been stacking this with my morning routine — taken it with breakfast alongside a few other things. Hard to attribute specific changes to any one supplement but my energy through long work days does feel steadier than before. I had a NAD+ blood test done before starting and plan to retest. The price is what it is, but given it's coming straight from the people who actually developed the ingredient, feels like the right source.
6 months ago
Did a fair amount of reading before committing to this dose. Knew I wanted NR specifically rather than NMN, and at 1000mg this is meaningfully higher than the standard offerings. Takes a few weeks before you feel anything — or think you do, hard to be objective — but I've noticed I'm sleeping more soundly. Will continue.
6 months ago
Recommended by my GP who has an interest in longevity medicine. Takes it himself apparently. Enough said.
7 months ago
I was sceptical. I've tried a lot of supplements that promised energy support and delivered very little. This one I noticed after about three weeks — afternoon slumps are less pronounced. I take it mid-morning with food. Not cheap but for something I actually feel, I'll keep buying it.
8 months ago
The formulation seems solid and I've no complaints about how it's made me feel over the past couple of months — less of that mid-afternoon fog. My only gripe is that at 1000mg you're taking two capsules per serving, and the bottle runs out faster than I'd like given the price. Would prefer a larger container size or bulk-buy option. Happy to reorder but it stings a little each time.
8 months ago
Started this after reading about NAD+ and mitochondrial health in the context of hormonal changes. I'm not making any bold claims but alongside other lifestyle changes I do feel sharper and more resilient on difficult days. I appreciate that this is the originator brand — I looked into a few cheaper alternatives and realised they were just reselling the same ingredient anyway, often at a lower dose.
A blood test is the only way to know what your body actually needs. We’ll tell you which of these supplements is right for you.
Find your panel
A curated selection of products, tools and rituals, chosen by our doctors.
Loading the catalogue…