Folate - L-5-MTHF

Name: Folate - L-5-MTHF
Brand: Thorne
SKU: product-0220
Price: 20.00 GBP
Availability: InStock
Rating: 4.8 (39 reviews)

£20.00

Thorne's Folate supplies L-5-methyltetrahydrofolate (L-5-MTHF), the biologically active form of folate that the body uses directly, without the conversion step required by folic acid.

Active folate for those with MTHFR gene variants
Supports healthy homocysteine levels in the blood
Critical nutrient for early pregnancy and neural tube development
Contributes to DNA synthesis and normal cell division
Bioavailable form — no conversion step required

4.8 (39 reflections)

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ThorneFolate - L-5-MTHF

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About This Product.

Thorne's Folate supplies L-5-methyltetrahydrofolate (L-5-MTHF), the biologically active form of folate that the body uses directly, without the conversion step required by folic acid. A meaningful proportion of the population carries variants in the MTHFR gene that reduce their ability to convert synthetic folic acid into this usable form. For those individuals — and for anyone wanting reliable folate status — L-5-MTHF is the more dependable choice.

Folate is a B-vitamin with well-established roles in DNA synthesis, cell division, and the methylation cycle. Adequate methylation underpins everything from neurotransmitter production to homocysteine regulation. Elevated homocysteine is a recognised cardiovascular risk marker, and folate is one of the key nutrients studied for keeping it in range. Folate is also critical in early pregnancy: sufficient intake before and during the first trimester is strongly associated with reduced risk of neural tube defects, making this a first-line supplement for anyone planning a pregnancy or in the early weeks.

This suits people with confirmed MTHFR variants, those with elevated homocysteine on a blood panel, women of childbearing age, and anyone whose diet is low in leafy greens and legumes. Thorne is a brand our doctors use routinely in clinical practice, chosen for its manufacturing standards and consistent use of bioavailable ingredient forms rather than cheaper synthetic alternatives.

Frequently Asked.

What is the difference between L-5-MTHF and folic acid?

Folic acid is a synthetic form of folate that the body must convert into L-5-MTHF before it can be used. People with common MTHFR gene variants convert it less efficiently. L-5-MTHF bypasses that step entirely, providing the active form the body can use directly.

Do I need a genetic test before taking this?

No. While knowing your MTHFR status can be informative, L-5-MTHF is safe for the general population and is simply a more bioavailable choice regardless of genetics. If you have concerns about your methylation or homocysteine levels, a blood panel is a sensible starting point.

Is this suitable to take during pregnancy?

Folate is a recommended supplement before conception and throughout the first trimester. However, confirm the correct dose for your situation with your GP or midwife, as requirements can vary.

Can I take this alongside a B-complex or prenatal multivitamin?

It is worth checking the folate content of any other supplement you are already taking to avoid unintentionally high combined intake. Review with your doctor or pharmacist if you are unsure.

How long does it take to see a difference in folate or homocysteine levels?

Blood folate levels typically respond within a few weeks of consistent supplementation, while changes in homocysteine may take longer to become apparent on a panel. Retesting after 8–12 weeks is a reasonable way to assess your response.

Customer Reflections

Overall Sentiment

4.839 reflections

1 – 6 of 39 reflections

Finally the right form of folate

4 months ago

Found out I have an MTHFR variant last year and switched to this from standard folic acid. My homocysteine came down noticeably on my next blood panel. Small capsule, easy to swallow, no stomach issues. Very happy with this one.

A proper prenatal folate

4 months ago

Started taking this as soon as we decided to try for a baby. My GP had mentioned the MTHFR gene issue and suggested looking into methylated folate. This ticks every box — decent dose, no fillers I can't pronounce, and the capsules are tiny. Three months in and I feel good about my choice.

Does exactly what I need

5 months ago

Takes about a week to settle into a routine with any new supplement, but this one's been seamless. Part of my B-vitamin stack alongside B12. No complaints.

Good product, pricey for what you get

5 months ago

The quality is clearly there — I've done my research on bioavailable forms of folate and this is one of the better options on the market. My only issue is the price relative to the number of capsules in the bottle. At £19.99 you're getting through it faster than you'd like if you're taking it daily. Still buying it though.

Recommended by my nutritionist

5 months ago

She specifically said to look for L-5-MTHF rather than folic acid. This was her top suggestion and I've been taking it for two months. Can't say I've felt a dramatic difference but my follow-up blood work showed homocysteine within range, which is the point.

5 months ago

Switched over after my naturopath flagged my MTHFR result. Solid supplement, no side effects, will keep ordering.

Folate - L-5-MTHF

About This Product.

How to Take It

Frequently Asked.

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