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Magnesium deficiency is more common than most people realise, and the form of magnesium matters. We recommend Thorne's bisglycinate specifically because the chelated form is well-tolerated and better absorbed than cheaper oxide alternatives. Thorne is a brand our clinicians return to consistently — their manufacturing standards are a known quantity, and this formulation is appropriate for patients managing sleep, muscle recovery, or confirmed low magnesium on a blood panel.
About this product
Magnesium Bisglycinate
Thorne Magnesium Bisglycinate is a chelated magnesium supplement in which magnesium is bound to the amino acid glycine. This binding method — bisglycinate, sometimes called glycinate — is chosen specifically because it tends to be better absorbed in the gut than oxide or citrate forms, and is generally gentler on the digestive system. Magnesium is involved in over 300 enzymatic processes in the body, including muscle contraction and relaxation, nerve signalling, and the regulation of sleep-wake cycles.
This supplement suits people who have identified low magnesium intake through diet or confirmed deficiency via a blood panel, those who experience disrupted sleep or difficulty switching off at night, and athletes or active individuals managing muscle tension and recovery during training blocks. It is also a common choice for anyone who has found other magnesium forms cause loose stools.
Glycine itself has a calming effect on the nervous system, which makes bisglycinate a particularly rational choice for evening use. Thorne is a brand with a well-established reputation in clinical nutrition, frequently used by practitioners who want consistent quality and formulation rigour. If you are managing a diagnosed deficiency, tracking progress with periodic blood testing is worthwhile to guide ongoing supplementation.
What it does
Benefits
- 01
Supports sleep quality and evening relaxation
- 02
Aids muscle relaxation and recovery after exercise
- 03
Chelated form for improved gastrointestinal tolerance
- 04
May help maintain healthy magnesium status in deficient individuals
- 05
Glycine component supports nervous system calm
Get the most from it
How to use
Take 3 capsules daily, as directed on the packaging. Magnesium bisglycinate is commonly taken in the evening, with or without food, given its association with relaxation and sleep support. If you are taking other supplements or medications, check with your GP or pharmacist before adding magnesium.
What's inside
Ingredients
View full ingredient list
Magnesium Bisglycinate
Common questions
Frequently asked
How does magnesium bisglycinate differ from other forms of magnesium?
Bisglycinate is a chelated form, meaning the magnesium is bound to glycine, an amino acid. This tends to improve absorption and is considerably gentler on the gut than magnesium oxide, which commonly causes loose stools at higher doses. Citrate is also well-absorbed but can have a laxative effect in some people; bisglycinate is typically the better-tolerated option.
When is the best time to take this?
Most people take magnesium bisglycinate in the evening, as magnesium is associated with muscle relaxation and may support sleep quality. It can be taken with or without food — the chelated form is less dependent on stomach acid for absorption than non-chelated forms.
How do I know if I actually need a magnesium supplement?
A serum or red blood cell magnesium test is the clearest way to confirm deficiency. Symptoms like muscle cramps, poor sleep, fatigue, and low mood can overlap with many conditions, so a blood test — available through your GP or a private panel — removes the guesswork before committing to supplementation.
Is it safe to take alongside other supplements or medications?
Magnesium can interact with certain medications, including some antibiotics, diuretics, and drugs for osteoporosis or heart conditions. Always check with your GP or pharmacist if you are on regular medication. Taking magnesium a couple of hours apart from other supplements is a reasonable general practice.
How long before I notice a difference?
This varies depending on how depleted your levels are. Some people notice improved sleep or reduced muscle tension within one to two weeks. If you are correcting a confirmed deficiency, retesting magnesium levels after 8 to 12 weeks of consistent supplementation gives a clearer picture of progress.
Doctor-guided care
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