1 / 4
Thorne Vitamin B12 provides methylcobalamin, the active, co-enzyme form of B12 that the body can use directly without conversion.
£20
Thorne Vitamin B12 provides methylcobalamin, the active, co-enzyme form of B12 that the body can use directly without conversion.
Thorne Vitamin B12 provides methylcobalamin, the active, co-enzyme form of B12 that the body can use directly without conversion.
Take 1 capsule one to three times daily or as recommended by your health professional.
Thorne Vitamin B12 provides methylcobalamin, the active, co-enzyme form of B12 that the body can use directly without conversion. This matters because a meaningful portion of people have reduced capacity to convert the more common cyanocobalamin form, particularly those with MTHFR gene variants or compromised digestive function.
B12 plays a central role in red blood cell formation, DNA synthesis, and the maintenance of myelin - the protective sheath around nerve fibres. Deficiency is associated with fatigue, poor concentration, tingling in the extremities, and low mood. It is especially common in people following plant-based diets, older adults (who absorb B12 less efficiently through the gut), and those who take long-term metformin or proton pump inhibitors.
This supplement suits anyone with confirmed low B12 on a blood test, or those in higher-risk groups who want a well-absorbed maintenance dose. The capsule format means it is straightforward to incorporate into a morning routine.
Thorne is a brand our clinicians regard as reliable for manufacturing standards and ingredient quality, and their choice of methylcobalamin over synthetic forms reflects a formulation philosophy we look for. For anyone uncertain whether B12 is genuinely relevant to them, a simple blood test is the most direct way to find out before supplementing.
Standard UK delivery included on every order, 1 to 3 working days after dispatch.
Next working day for £25 when you order by 12pm. Orders placed before 12pm on a working day leave the same day. Later orders leave the next working day.
You can return unopened and unused items within 30 days of delivery. This does not affect your statutory rights. Read the delivery and returns terms
Your Profile
Your first order creates it. Add your blood results or a wearable, and a doctor can recommend what suits you.
Sign inMethylcobalamin is the active co-enzyme form of B12, meaning the body can use it directly. Cyanocobalamin, the form in many cheaper supplements, must first be converted — a step that is less efficient in people with certain genetic variants (such as MTHFR) or poor digestive absorption.
People following vegan or vegetarian diets, older adults, those with atrophic gastritis or coeliac disease, and long-term users of metformin or proton pump inhibitors are at higher risk. A blood test is the most reliable way to confirm whether supplementation is warranted.
This depends on your baseline levels and the reason for supplementing. People correcting a genuine deficiency may notice improvements in energy and concentration within several weeks, though full repletion can take longer. If symptoms persist, revisit with your GP or clinician.
Generally yes, though it is worth checking whether your multivitamin already contains B12 to avoid unnecessary doubling up. If you are taking other supplements or medications, particularly methotrexate, check with your prescriber.
B12 is water-soluble and is generally well tolerated with or without food. Taking it in the morning, with or without a meal, is the most common approach and fits naturally into a daily routine.
Overall
6 months ago
Been taking this for about six weeks now after a blood test showed my B12 was on the low side. Started noticing I wasn't dragging myself through the afternoons anymore. Don't know if it's placebo but I'm inclined to think not — the timing lines up too well. Will keep reordering.
6 months ago
Was on a supermarket own-brand B12 for years and never felt much from it. A friend who works in nutrition suggested switching to methylcobalamin specifically. Can't say it's been dramatic but I do feel steadier — less of that mid-morning fog I'd put down to age.
6 months ago
Vegan for three years and finally took a blood test. My B12 was low. This sorted it out within a couple of months — follow-up test confirmed it. Easy to swallow, no aftertaste.
6 months ago
It does what it should — I've had two blood tests confirm my levels are now in range. My only hesitation is the price. Fourteen-odd pounds for one vitamin feels steep, especially when you're taking it alongside other supplements. That said, quality seems solid and I'd rather this than a cheap cyanocobalamin version.
7 months ago
I have an MTHFR variant and was told by my GP to stick to methylated forms of B vitamins. This fits the bill perfectly. Absorbed well, no digestive issues, and my fatigue has noticeably improved over two months of use.
7 months ago
Simple, effective. Takes up no space in my morning supplement routine. Levels back to normal at my last check.
Biomarker check, £350MaryleboneSee your vitamin D, iron and B12.At our clinic in Marylebone, London, doctors also offer private blood tests and longevity medicine.
A curated selection of products, tools and rituals, chosen by our doctors.
