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P5p 50

£25

P5P 50 by Pure Encapsulations delivers pyridoxal 5'-phosphate, the biologically active coenzyme form of vitamin B6.

Active B6 form, no liver conversion required
Studied for homocysteine regulation alongside B12 and folate
Relevant for B6-depleting medication use

4.8 (17 reflections)

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PURE EncapsulationsP5p 50

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Why We Love It.

P5P 50 by Pure Encapsulations delivers pyridoxal 5'-phosphate, the biologically active coenzyme form of vitamin B6. Unlike standard pyridoxine, P5P does not require hepatic conversion to become functional - it is ready for use by the body immediately. This matters for people with compromised liver function, certain genetic variants affecting B6 metabolism (including common MTHFR-adjacent polymorphisms), or those who have not responded well to standard B6 supplementation.

B6 as P5P is involved in over 100 enzymatic reactions, most notably in amino acid metabolism, the synthesis of neurotransmitters including serotonin, dopamine, and GABA, and the production of haemoglobin. It also plays a role in homocysteine regulation alongside folate and B12.

This supplement suits people with confirmed low B6 status on blood testing, those supporting mood and cognitive function under clinical guidance, women experiencing B6-responsive symptoms such as premenstrual mood changes or pregnancy-related nausea, and individuals on long-term medications known to deplete B6.

Pure Encapsulations is a practitioner-grade brand with a long-standing reputation for minimal excipient use and consistent formulation standards. The active form distinguishes this product from lower-cost pyridoxine supplements found on the high street.

Good to Know

A food supplement. Do not take more than the dose on the label.
Not a substitute for a varied, balanced diet and a healthy lifestyle.
Check with your doctor first if you are pregnant, breastfeeding, taking medication or under medical care.
Keep out of the reach of young children.

Frequently Asked.

What is the difference between P5P and regular vitamin B6?

Standard vitamin B6 supplements typically use pyridoxine, which must be converted by the liver into P5P before the body can use it. P5P is the active coenzyme form, so it bypasses that conversion step — particularly relevant if your liver function is compromised or if you carry genetic variants that slow the conversion process.

Who would benefit most from taking P5P specifically?

People with confirmed low B6 on a blood test, those on medications known to deplete B6 (such as certain oral contraceptives or isoniazid), women with B6-responsive premenstrual symptoms, and individuals managing elevated homocysteine alongside B12 and folate are all reasonable candidates. Speak to a clinician to confirm whether this form is appropriate for you.

Is it safe to take long term?

B6 supplementation at high doses over extended periods has been associated with peripheral neuropathy, so total daily intake from all sources should be monitored. At the dose in this product, use is generally considered appropriate under standard guidance, but ongoing use is best reviewed with a healthcare practitioner.

Can I take this alongside other B-vitamin supplements or a multivitamin?

Possibly, but check the B6 content across everything you are taking. Combining multiple B6-containing products can push total daily intake above levels considered safe for long-term use. A practitioner or pharmacist can help you assess your combined intake.

How will I know if it is working?

B6 status is measurable via blood testing — plasma pyridoxal 5'-phosphate is the most direct marker. Functional improvements (mood, energy, symptom relief) vary by individual and underlying reason for deficiency. If you started supplementing in response to a confirmed deficiency, retesting after 8 to 12 weeks gives the clearest picture.

Customer Reflections

Overall Sentiment

4.817 reflections

1 – 6 of 17 reflections

Finally switched from standard B6

6 months ago

Had been taking regular pyridoxine for months with no noticeable effect. My nutritionist suggested trying the active form instead and within a couple of weeks I noticed a real difference in my mood, especially in the week before my period. Small capsule, easy to take with breakfast. Reordering.

Works where regular B6 didn't

6 months ago

My GP flagged low B6 on a blood panel earlier this year. Tried a high-street supplement first and retested — levels barely moved. Switched to this and my follow-up bloods were much improved. Worth the extra cost for the active form.

Good product, bottle could be bigger

6 months ago

Does what I need it to. Taking it alongside methylfolate and methylcobalamin as part of a stack recommended by my functional medicine practitioner. No complaints about the formula itself — just 60 capsules goes quite quickly when you're taking it daily. Would prefer a 90-count option at this price point.

6 months ago

Bought on recommendation from my naturopath. Energy and mood both feel more stable, and my sleep has improved a bit too. I take it in the morning with food. Very clean formula — no unnecessary fillers.

Solid practitioner-grade supplement

6 months ago

Been using this for around six weeks. Part of a broader protocol to support homocysteine levels — along with B12 and folate. Hard to attribute everything to one supplement but my levels are trending in the right direction. Trusted brand, minimal ingredients.

7 months ago

Noticed a real improvement in PMS symptoms after about 3–4 weeks. Low mood and irritability in the luteal phase have both lessened noticeably. I was sceptical but the difference has been consistent over two cycles now.

P5p 50

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